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Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression

Dimitrios Panutsopulos, Alexandros Zafiropoulos, Elias Krambovitis, George E Kochiadakis, Nikos E Igoumenidis and Demetrios A Spandidos*

Journal of Translational Medicine 2003, 1:6  doi:10.1186/1479-5876-1-6

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PAI-1 excess and decrease active MMPs impair monocyte migration in diabetes

Melvin Hayden   (2003-12-10 16:02)  Department of Family and Community Medicine University of Missouri School of Medicine email

Congratulations on an excellent article.

In additon to increased bFGF and VEGF in diabetic peripheral monocytes, have you considered the elevation in PAI-1 levels as being implicated in the Vascular Paradox of diabetes: Accelerated angiogenesis and impaired arteriogenesis (collateral formation)?

Excess PAI-1 would result in a decrease in Plasmin, which converts latent MMPs to active MMPs.

If latent MMP activation is impaired then the extracellular matrix would not be digested and thus impair the migration of the monocyte within the extracellular matrix [1].

1. Hayden MR, Tyagi SC: Arteriogenesis: Angiogenesis within Unstable Atherosclerotic Plaque-- Interactions with Extracellular Matrix.

Curr Interv Cardiol Rep. 2000 Aug;2(3):218-227

Thank you for your excellent article and I would appreciate any comments you might have regarding this issue as it seems to relate to your excellent publication.


M.R. (Pete) Hayden, M.D.

Adjunct Assistant Professor

Department of Family and Community Medicine

University of Missouri School of Medicne

Competing interests



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