Open Access Research

Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode

Qiong-Lin Liang1, Xiao-Ping Liang12, Yi-Ming Wang1, Yuan-Yuan Xie1, Rong-Li Zhang1, Xi Chen1, Rong Gao1, Yi-Jun Cheng12, Jun Wu3, Qing-Bo Xu4, Qing-Zhong Xiao5, Xue Li1, Shu-Feng Lv12, Xue-Mei Fan1, Hong-Yang Zhang12, Qing-Li Zhang12 and Guo-An Luo126*

Author Affiliations

1 Department of Chemistry, Beijing Key Laboratory for Microanalytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China

2 School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

3 Xiangxue Pharmaceutical, Guangzhou 510530, China

4 Kings College London, London SE5 9NU, UK

5 London School of Medicine and Dentistry, Queen Mary University of London, London SE5 9NU, UK

6 Modern Research Center for Traditional Chinese Medicine, Tsinghua University, Beijing 100084, PR China

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Journal of Translational Medicine 2012, 10:26  doi:10.1186/1479-5876-10-26

Published: 8 February 2012

Abstract

Background

Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF.

Method

In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI.

Results

Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage.

Conclusions

The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.