Open Access Research

Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide

Julio D Duarte12*, Issam Zineh13, Ben Burkley1, Yan Gong1, Taimour Y Langaee1, Stephen T Turner4, Arlene B Chapman5, Eric Boerwinkle6, John G Gums1, Rhonda M Cooper-DeHoff1, Amber L Beitelshees7, Kent R Bailey8, Roger B Fillingim9, Bruce C Kone1011 and Julie A Johnson1

Author Affiliations

1 Center for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA

2 Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL 60612, USA

3 Office of Clinical Pharmacology, Office of Translational Sciences - CDER, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA

4 Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA

5 Renal Division, Department of Medicine, Emory University, Atlanta, GA 30322, USA

6 Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA

7 Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA

8 Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA

9 Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA

10 Division of Nephrology, Hypertension & Renal Transplantation, University of Florida, Gainesville, FL 32610, USA

11 Division of Renal Diseases and Hypertension, University of Texas Health Science Center, Houston, TX 77030, USA

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Journal of Translational Medicine 2012, 10:56  doi:10.1186/1479-5876-10-56

Published: 22 March 2012

Additional files

Additional file 1:

Supplementary Table 1. SNPs genotyped in SGK1, DOT1L, SIRT1, and MLLT3 gene regions.

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