Table 2

Differences of white matter integrity (FA values) of the 5 patients who showed neurodevelopmental improvement

ROIs

UPN 8

UPN 9

UPN 11

UPN 12

UPN 13

Pre

Post

Pre

Post

Pre

Post

Pre

Post

Pre

Post


Temporal

TR *

0.431

0.451

0.438

0.421

0.425

0.445

0.463

0.464

0.416

0.430

TL

0.483

0.457

0.448

0.456

0.319

0.346

0.460

0.444

0.423

0.460

Orbito-frontal

FR

0.411

0.465

0.470

0.378

0.359

0.386

0.421

0.438

0.466

0.728

FL

0.469

0.490

0.450

0.383

0.319

0.336

0.423

0.438

0.462

0.450

Inferior frontal

IFR

0.453

0.446

0.444

0.447

0.397

0.370

0.404

0.437

0.443

0.474

IFL

0.506

0.515

0.494

0.383

0.320

0.334

0.457

0.464

0.452

0.454

Internal capsule

ICR

0.489

0.499

0.498

0.570

0.501

0.534

0.476

0.498

0.467

0.465

ICL

0.527

0.520

0.493

0.504

0.336

0.328

0.496

0.496

0.478

0.454

CC *

0.534

0.538

0.493

0.487

0.421

0.427

0.443

0.509

0.481

0.447

S

0.502

0.536

0.472

0.495

0.421

0.421

0.512

0.549

0.471

0.465

Periventricular white matter

AWMR

0.374

0.366

0.363

0.300

0.363

0.369

0.363

0.307

0.373

0.332

AWML

0.423

0.385

0.375

0.315

0.264

0.228

0.349

0.371

0.332

0.378

PWMR*

0.479

0.479

0.400

0.425

0.426

0.481

0.407

0.415

0.398

0.408

PWML

0.488

0.484

0.476

0.442

0.314

0.392

0.459

0.444

0.414

0.410

Occipital

OR

0.443

0.457

0.523

0.449

0.441

0.446

0.450

0.430

0.414

0.434

OL

0.483

0.510

0.488

0.395

0.284

0.271

0.536

0.509

0.441

0.391

Sup frontal subcortex

SFR

0.475

0.447

0.484

0.444

0.346

0.330

0.345

0.431

0.452

0.433

SFL

0.455

0.460

0.443

0.360

0.308

0.334

0.399

0.401

0.452

0.440

Middle frontal paravent WM

MFPAR

0.336

0.319

0.363

0.379

0.389

0.396

0.378

0.381

0.389

0.414

MFPAL

0.455

0.447

0.433

0.389

0.263

0.237

0.385

0.387

0.387

0.438

Parietal perivent WM

PPER

0.468

0.451

0.447

0.440

0.466

0.504

0.446

0.479

0.435

0.445

PPEL

0.519

0.514

0.458

0.456

0.342

0.350

0.453

0.458

0.446

0.453

Post parietal perivent WM

PPPER

0.467

0.507

0.405

0.467

0.477

0.495

0.492

0.488

0.391

0.476

PPPEL

0.465

0.466

0.464

0.427

0.284

0.284

0.452

0.525

0.408

0.372

Post parietal paravent WM

PPPAR

0.445

0.497

0.336

0.412

0.480

0.477

0.433

0.473

0.425

0.508

PPPAL

0.441

0.443

0.381

0.359

0.273

0.288

0.448

0.422

0.374

0.425


UPN; unique patient number, TR; right temporal, TL; left temporal, FR; right orbito-frontal, FL; left orbito-frontal, IFR; right inferior frontal, IFL; left inferior frontal, ICR; right internal capsule, ICL; left internal capsule, CC; corpus callosum, S; splenium, AWMR; right anterior periventricular white matter, AWML; left anterior periventricular white matter, PWMR; right posterior periventricular white matter, PWML; left posterior periventricular white matter, OR; right occipital, OL; left occipital, SFR; right superior frontal subcortex, SFL; left superior frontal subcortex, MFPAR; right anterior middle frontal paraventricular white matter, MFPAL; left anterior middle frontal paraventricular white matter, PPER; right parietal periventricular white matter, PPEL; left parietal periventricular white matter, PPPER; right posterior parietal periventricular white matter, PPPEL; left posterior parietal periventricular white matter, PPPAR; right posterior parietal paraventricular white matter, PPPAL; left posterior parietal paraventricular white matter (* indicates the ROIs demonstrated significant differences between pre-treatment and post-treatment values out of 26 ROIs.)

Lee et al. Journal of Translational Medicine 2012 10:58   doi:10.1186/1479-5876-10-58

Open Data