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This article is part of the supplement: Proceedings of the 2012 Sino-American Symposium on Clinical and Translational Medicine (SAS-CTM)

Open Access Meeting abstract

Magnetic resonance imaging for translational and basic life sciences

Ed X Wu

Author Affiliations

Department of Electrical and Electronic Engineering, the University of Hong Kong, Hong Kong SAR, China

Laboratory of Biomedical Imaging and Signal Processing, the University of Hong Kong, Hong Kong SAR, China

Medical Engineering Program, the University of Hong Kong, Hong Kong SAR, China

Journal of Translational Medicine 2012, 10(Suppl 2):A29  doi:10.1186/1479-5876-10-S2-A29


The electronic version of this article is the complete one and can be found online at: http://www.translational-medicine.com/content/10/S2/A29


Published:17 October 2012

© 2012 Wu; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

With advances in engineering and computing, an extraordinary body of imaging technologies and applications has developed over the last 35 years. One of the most important applications of such technologies is the study of anatomy, physiology, pathology and functions in humans and animal models of human development and diseases. Among the various in vivo and non-invasive imaging modalities available or under development today, magnetic resonance imaging (MRI) is the most powerful and versatile technology platform. Its unparalleled in vivo and quantitative capabilities offer a broad range of applications covering from noninvasive morphologic measurements, tissue microstructural characterization, hemodynamic and vascular characterization, metabolite measurements, sub-system physiologies, brain functions to monitoring of cell migrational dynamics. This presentation will illustrate these technological developments with some of the ongoing rodent brain MRI projects in our laboratory, highlighting the capacity of MRI as a platform technology to visualize the central nervous system (CNS) in vivo from molecules to systems levels. They include diffusion characterization of neural tissue microstructure; functional study of molecular pathways by spectroscopy; functional study of brain development and injury; monitoring of endogenous neural stem cell activities; and novel contrast agents for brain imaging.