Granzyme B; the chalk-mark of a cytotoxic lymphocyte

doi:10.1186/1479-5876-2-36

Journal of Translational Medicine

Volume 2

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Commentary

Granzyme B; the chalk-mark of a cytotoxic lymphocyte

Nigel J Waterhouse , Karin A Sedelies and Chris JP Clarke

Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, 8006, Australia

author email corresponding author email

Journal of Translational Medicine 2004, 2:36doi:10.1186/1479-5876-2-36


Published:	25 October 2004

Abstract

During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this way, the released granzyme B can be used to mark the spot where a target cell was murdered. We discuss the benefits and potential limitations of using this assay to measure CL mediated killing of target cells.