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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Bernard Escudier1* email, Thierry Dorval2* email, Nathalie Chaput3 email, Fabrice André3 email, Marie-Pierre Caby4 email, Sophie Novault3 email, Caroline Flament3 email, Christophe Leboulaire3 email, Christophe Borg3 email, Sebastian Amigorena4 email, Catherine Boccaccio5 email, Christian Bonnerot4 email, Olivier Dhellin6 email, Mojgan Movassagh3 email, Sophie Piperno2 email, Caroline Robert3,9 email, Vincent Serra6 email, Nancy Valente7 email, Jean-Bernard Le Pecq6,7 email, Alain Spatz8 email, Olivier Lantz4 email, Thomas Tursz1,3 email, Eric Angevin1,3 email and Laurence Zitvogel1,3 email

1  Department of Immunotherapy, Institut Gustave Roussy, Villejuif, France

2  Department of Clinical Oncology, Institut Curie, Paris, France

3  ERM0208 INSERM, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France

4  U520INSERM, Institut Curie, Paris, France

5  Cell Therapy Unit, Institut Gustave Roussy, Villejuif, France

6  Anosys S.A, Evry, France

7  Anosys Inc, Menlo Park, California, USA

8  Department of Pathology, Institut Gustave Roussy, Villejuif, France

9  Department of Dermatology, Institut Gustave Roussy, Villejuif, France

author email corresponding author email* Contributed equally

Journal of Translational Medicine 2005, 3:10doi:10.1186/1479-5876-3-10

Published: 2 March 2005

Additional files

Additional File 1:

Dosing, demographic, base line data and clinical outcome

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