Table 2

Higher Detection Frequency in Neuronal Cells

Protein Name
Abbreviation
Accession #
Functional Category

Alkaline Phosphatase
PPBT
Q29486
Membrane Phosphatase
Aminopeptidase N
AMPN
P79171
Membrane Enzyme
Arylsulfatase B precursor
ARSB
P33727
Lysosomal Enzyme
Brain-derived neurotrophic factor precursor
BDNF*
Q9TST3
Neurotrophic Factor
Cellular tumor suppressor p53
P53*
P41685
Nuclear
Dipeptidyl peptidase IV
DPP4
Q9N2I7
Membrane Enzyme
Glutamate decarboxylase, 67 kDa isoform
DCEI
P14748
Cytoplasmic Enzyme
Integrin beta-1 precursor
ITB1
P53713
Membrane Receptor
Interleukin-1 beta convertase precursor
ICE1
Q9MZV6
Cytoplasmic Enzyme
Lysosomal alpha-mannosidase precursor
M2B1
O46432
Lysosomal Enzyme
Major prion protein precursor
PRIO
O18754
Membrane Prion Protein
Mast/stem cell growth factor receptor precursor
KIT
Q28889
Membrane Tyrosine Kinase Receptor
NADH-Ubiquinone oxidoreductase chain 5
NU5M
P48921
Mitochondrial Enzyme
Polycomb complex protein BMI-1
BMI1
Q9TST0
Nuclear Protein
Pyruvate kinase, M1 isozyme
KPYM
P11979
Pyruvate Kinase
Serum albumin precursor***
ALBU*
P49064
Cytoplasmic Albumin Protein
Sodium/calcium exchanger 1 precursor
NAC1
P48767
Membrane Calcium Ion Channel (Plasma Membrane)
T-cell surface glycoprotein CD8 beta chain precursor
CD8B
P79336
Membrane Receptor
Toll-like receptor 4 precursor
TLR4
P58727
Membrane Receptor
Transferrin receptor protein 1
TFR1
Q9MYZ3
Membrane Receptor
Zona pellucida sperm-binding protein 2 precursor
ZP2*
P47984
Membrane Receptor
Zona pellucida sperm-binding protein B precursor
ZP4
P48834
Membrane Receptor

Proteins with higher frequency of detection in complex forms in neuronal cells compared to melanoma. Ten proteins were detected in single as well as in complex forms in both melanoma and neuronal cells. These proteins displayed a higher frequency of detection in neuronal cells than in melanoma. Four proteins Fel d 2 /ALBU*, BDNF*, tumor suppressor protein (P53*) and zona pellucida-2 (ZP2*) were detected both in single (*) and complex forms only in neuronal cells. These proteins were present only in complexes in melanoma cells. The ALBU and P53* proteins also showed increased frequency of detection in the neuronal cells than in melanoma (also see Fig 2C*) and BDNF and ZP2 showed similar detection frequencies in the two cell types.

Rasheed et al. Journal of Translational Medicine 2005 3:14   doi:10.1186/1479-5876-3-14