|
44 Signature Genes that are Interferon Related |
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| Gene |
Function/Association |
Alias |
Induced by most IFN-α's |
Induced by IFN-β |
Ref |
|
|
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| SP110 |
nuclear body protein |
Interferon-induced protein 41/75 |
yes |
yes |
16 |
| C1Orf29 |
Unknown |
yes |
yes |
none |
|
| ISG20 |
IFN stimulated genes |
HEM45 |
yes |
yes |
17–18 |
| TNFSF13B |
TFN superfamily |
BAFF BAFF BLYS HGNC:13472 TALL-1 THANK TNFSF20 ZTNF4 (L |
yes |
yes |
19 |
| ITGA5 |
Integrin-alpha 5 (receptor for fibrinogen and fibronectin) |
CD49e, FNRA, VLA5A, fibronectin receptor (alpha subunit), integrin alpha 5 |
yes |
yes |
20 |
| Mx1 |
Mixovirus resistence |
yes |
no |
21 |
|
| IFRG28 |
IFN responsive, potential type III membrane protein |
yes |
no |
none |
|
| CXCL10 |
CXC family |
C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, chemokine (C-X-C motif) ligand 10, gamma IP10 |
yes |
yes |
22,23 |
| OAS2 |
2'5'OAS 2 |
yes |
yes |
24 |
|
| OAS1 |
2'5'OAS 1 |
yes |
yes |
25 |
|
| TRIM22 |
STAF 50 |
GPSTAF50, RNF94, STAF50-PEN, Stimulated Trans-Acting Factor |
yes |
yes |
25,26 |
| UBE2L6 |
Ubiquitin conjugated enzyme |
MGC40331, RIG-B, UBCH8, retinoic acid induced gene B protein, ubiquitin carrier protein, ubiquitin-conjugating enzyme E2L 6, ubiquitin-protein ligase, Ubiquitin-conjugating enzyme |
yes |
yes |
27 |
| Ly6E |
Lymphocyte antigen complex |
LY6, RIG-E, RIGE, SCA-2, SCA2, TSA-1 |
yes |
yes |
28 |
| IFITM3 |
IFN-induced transmembran protein |
1-8U |
yes |
no |
29,30 |
| GMPR |
Guanosine monophosp reductase |
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP |
yes |
no |
none |
| PSME2 |
PA28 Proteasome subunit |
PA28B, PA28beta, REGbeta, 11S regulator complex beta subunit, MCP activator |
yes |
yes |
31, 32 |
| PSMB9 |
Proteasome subunit |
LMP2, RING12 |
yes |
yes |
32 |
| GBP1 |
Binds GTP, GDP and GMP |
Interferon-induced guanylate-binding protein 1 |
yes |
yes |
33 |
| NUP155 |
nucleoporin |
KIAA0791, N155 |
yes |
yes |
none |
| CIG5 |
antiviral protein induced by CMV |
vig1, Viperin |
yes |
yes |
34 |
| LAP3 |
Signal transducer |
HGNC:8843, LAP, LAPEP, PEPS |
yes |
yes |
35 |
| Stat1 |
Transcription factor that binds to the ISRE and GAS elements |
ISGF-3, STAT91 |
yes |
yes |
36 |
| PRIC 285 |
helicase |
FLJ00244, KIAA1769 |
yes |
yes |
none |
| TRAF5 |
adapter protein and signal transducer |
MGC:39780, RNF8 |
yes |
yes |
none |
| KIAA1268 |
unknown |
yes |
yes |
none |
|
| NTRK2 |
tyrosine kinases receptor |
TRKB |
yes |
yes |
37 |
| ZC3HDC1 |
zinc finger CCCH-type domain |
yes |
yes |
none |
|
| BST2 |
bone marrow stromal antigen |
yes |
yes |
none |
|
| LIPC |
lipase, hepatic |
HL, HTGL, LIPH, lipase hepatic |
yes |
no |
none |
| IFI44 |
interferon-induced, hepatitis C-associated microtubular aggregate protein |
MTAP44 |
yes |
yes |
38 |
| IFIT2 |
IFN-α inducible protein |
G10P2, GARG-39, IFI-54, IFI54, ISG-54K, cig42, Interferon alpha-inducible protein |
yes |
yes |
39, 40 |
| G1P2 |
IFN-α inducible protein, Ubiquitin cross-reactive protein precursor |
IFI15, ISG15, UCRP |
yes |
yes |
27 |
| G1P3 |
IFN-α inducible protein |
6–16, IFI616, interferon, alpha-inducible protein |
yes |
no |
41 |
| Mx2 |
myxo resistance |
yes |
no |
21 |
|
| IFIT1 |
IFN-α inducible protein |
G10P1, GARG-16, IFI-56, IFI56, IFNAI1, RNM561 |
yes |
no |
42 |
| PRKR |
Interferon-induced, double-stranded RNA-activated protein kinase |
EIF2AK1, PKR, interferon-inducible elF2alpha kinase |
yes |
yes |
43 |
| OAS3 |
2'5'OAS 3 |
p100, 2'-5'-oligoadenylate synthetase 3 |
yes |
yes |
24 |
| LOC129607 |
hypotetical protein |
yes |
yes |
none |
|
| Cyclin E binding protein 1 |
ubiquitin-protein ligase, regulation of cyclin dependent protein kinase activity |
CEBP1, HECT E3 ubiquitin ligase |
yes |
no |
44 |
| DXD58 |
Retinoic acid-inducible gene |
RIG-I, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
yes |
no |
45 |
| USP18 |
ubiquitin specific protease 18 |
ISG43, UBP43, ubiquitin specific protease 18 |
yes |
no |
46, 47 |
| PRSS21 |
protease serine, Could regulate proteolytic events associated with testicular germ cell maturation. |
ESP-1, TEST1, testisin |
yes |
no |
none |
| IRF7 |
IFN regulatory factor 7 |
yes |
yes |
48 |
|
| PLA2G4B |
phospholipase A2 |
CPLA2-BETA, HsT16992, PLA2G4B protein |
yes |
yes |
49 |
|
* Interferon γ only | |||||
Stroncek et al. Journal of Translational Medicine 2005 3:24 doi:10.1186/1479-5876-3-24 |
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