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Xipeng Wang, Ena Wang, John J Kavanagh and Ralph S Freedman*
Corresponding author: Ralph S Freedman email@example.com
Journal of Translational Medicine 2005, 3:25 doi:10.1186/1479-5876-3-25
Peter R Main
(2006-01-02 08:28) School of Information Science and Engineering, Canberra University
Wang et al provide an extensive and logical review of inflammatory and thrombotic
controls possibly operant via angiogensis and other systems, evident in ovarian cancer
and its peritoneal response.
Such a system has features of "niche construction" in complex adaptive systems (CAS)
useful in ecosystems modeling. In such systems there appears a major problem of dealing
with dynamic adaptive diversity (ie rapid mutation that alters the crosstalk being
used by the cancer to control host cell lines). Adaptation of tumour to therapeutic
challenges is a well established mode of failure in therapies.
This diversity of a CAS subject to control intervention, needs to be formally considered,
when planning the early clinical extension of their work to interventions of thrombotic
or inflammatory pathways.
Wang et al's report does not consider diversity as central to their topic, yet diversity
is central to both the underlying inflammatory /thrombotic / angiogenic systems, and
their modulation by tumour. Diversity of these systems may be central to future clinical
failure to translate theory to therapy -we do not yet know.
A significant further sampling of the 402 genes differentially expressed in malign
vs benign peritoneum, and 663 genes differentially expressed in malign vs benign stroma,
may reflect expression diversity, of immediate relevance to planning clinical interventions.
Finally, In my view, for a progressive epublication paradigm, I suggest a minimum
additional requirement for such published analysis, is the online deposition of the
genetic data background to their report. That at least would enable future cross-checking
of relevant involved genes in meta-analysis of new reports with past reports.
Fragmentation of isolated bits of data, across time, geography and language, is surely
a shamefully obsolete practice belonging to horse and buggy days, not modern worldwide
To my knowledge I have no competing interests relevant to the above comments, or
the commented journal report.
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