Figure 8.

Histology of teratoma induced by ESC injection. Teratoma was induced by injection of ESC into SCID mouse testis. Ectodermal differentiation is observed with basophilic staining in a cord-like distribution, typical neural tissue organization (a1), and neuronal rosette (a1 inset). Squamous epithelium shows normal keratin deposition pattern (a2). Mesodermal components include cartilage (b1) and striated muscle (b2). Endodermal differentiation to a gut-like structure lined with mucinous epithelium (c1). Cells organized in acinar structure typical of glands (pancreas or salivary) (c2).