Table 2

Established anti-tumor activities of IL-1 blocking methods and/or therapies based on published literature.

Study

Year

Observation


Voronov et al [7]

2003

IL-1 KO mice failed to develop solid tumors post injection of melanoma cells and exhibited significantly improved survival compared with wild type animals.

Saijo et al [19]

2002

Overexpression of IL-1 is associated with an aggressive/malignant phenotype.

Sawai et al [22]

2003

Same observation as above

Voronov et al [7]

2003

Same observation as above

Weinreich et al [28]

2003

IL-1ra-transduced xenografts exhibited decreased tumor growth and metastases in murine models.

Elaraj et al [15]

2006

Exogenously administered IL-1ra (anakinra) decreased tumor proliferation rate, metastases, and IL-8 and VEGF mRNA expression of xenografts in murine models.


Lewis et al. Journal of Translational Medicine 2006 4:48   doi:10.1186/1479-5876-4-48

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