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DC-specific genes that are over-expressed in spleen of Immune Mice. Values within square brackets [] represent the fold increase in the expression of each gene by mice vaccinated with semi-allogeneic vaccines compared to mice mock-vaccinated with PBS. These over-expressed genes are in addition to those listed in Table 1. |
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| DC-SIGN [4.0] (CD209a) |
A cell surface C-type lectin expressed by dendritic cells that mediates antigen capture for processing and presentation |
| CD28 [1.6] |
T cell-specific receptor for CD80 and CD86 |
| CD83 [1.9] |
The most reliable activation marker for mature dendritic cells |
| FAS [2.1] |
The apoptosis-mediating membrane-associated polypeptide that belongs to the tumor necrosis factor receptor superfamily |
| Flt3L [1.7] |
A ligand that expands type-1 dendritic cells and enhances the immune response by augmenting T-cell activity |
| H2-DMa [2.0] |
Involved in antigen processing and presentation of exogenous peptide antigens via MHC class II |
| ICOSL [2.6] (B7-H2) |
Is a ligand for T cell-specific, cell surface receptor ICOS and acts as a co-stimulatory signal for T-cell proliferation and cytokine secretion |
| CD11c [1.7] (ITGAX) |
Expressed by dendritic cells that tend to generate Th1 effectors |
| LTA [1.7] (TNF-β) |
Lymphotoxin α or tumor necrosis factor β |
| NFKB [1.5] |
A transcription factor required for STAT-4 expression during dendritic cell maturation |
| XCL1 [2.5] (ATAC) |
An activation-induced, T cell-derived and chemokine-related type 1 cytokine, that cooperates with interferon (IFN)-γ in the up-regulation of CD40 and interleukin (IL)-12 expression |
Yu et al. Journal of Translational Medicine 2007 5:39 doi:10.1186/1479-5876-5-39 |
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