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Belinostat induces P21WAF1 and other HDAC core genes in transgenic mice bladders. Summary of changes in transgenic mice bladder gene expression for belinostat-treated versus control |
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| Gene Name |
Gene Symbol |
Gene Function |
Fold Change |
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| Acidic nuclear phosphoprotein 32 family, member B |
Anp32b |
Cell cycle |
1.2 |
| Clusterin |
Clu |
Cell death/apoptosis |
-2.2 |
| Cyclin-dependent kinase inhibitor 1A |
P21 |
Cell cycle regulation |
1.5 |
| Cytidine 5'-triphosphate synthase |
Ctps |
DNA synthesis |
1.8 |
| Dehydrogenase/reductase (SDR family) member 3 |
Dhrs3 |
Short chain alchol dehydrogenase |
1.3 |
| Dehydrogenase/reductase (SDR family) member 4 |
Dhrs4 |
Short chain alchol dehydrogenase |
-1.4 |
| Dehydrogenase/reductase (SDR family) member 7 |
Dhrs7 |
Short chain alchol dehydrogenase |
1.3 |
| Dehydrogenase/reductase (SDR family) member 8 |
Dhrs8 |
Short chain alchol dehydrogenase |
1.5 |
| Fucosidase, alpha-L-1, tissue |
Fuca1 |
Proteoglycan metabolism |
1.6 |
| Glutaredoxin 1 (thioltransferase) |
Glrx1 |
Glutathione dep DNA synthesis |
1.3 |
| Glutaredoxin 2 (thioltransferase) |
Glrx2 |
Glutathione dep DNA synthesis |
1.2 |
| Hepatoma-derived growth factor |
hdgf |
Transformation related protein |
1.3 |
| Hepatoma-derived growth factor |
hdgf |
Transformation related protein |
2.9 |
| Histone 2, H2be |
Hist2h2bb |
Nucelear organization |
-1.6 |
| Karyopherin (Importin) beta 1 |
kpnb1 |
Nucelear translocation |
-1.6 |
| Karyopherin (Importin) beta 1 |
kpnb1 |
Nucelear translocation |
1.1 |
| Karyopherin (Importin) beta 1 |
kpnb1 |
Nucelear translocation |
1.4 |
| Metalliothionine 1 |
Mt1 |
Binds heavy metals |
4.3 |
| Tubulin, alpha 2 |
Tuba2 |
Cytoskeletal structure |
1.1 |
| Tubulin, alpha 4 |
Tuba4 |
Cytoskeletal structure |
-1.7 |
| Tubulin, alpha 6 |
Tuba6 |
Cytoskeletal structure |
-1.2 |
| Tubulin, alpha 6 |
Tuba6 |
Cytoskeletal structure |
1.2 |
Buckley et al. Journal of Translational Medicine 2007 5:49 doi:10.1186/1479-5876-5-49 |
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