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Phenotypic Characterization of ERC |
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| Marker |
Relevance |
Expression |
|
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| CD14 |
Monocyte marker |
Negative |
| CD34 |
Hematopoietic stem cell marker |
Negative |
| CD38 |
Differentiating hematopoietic stem cell marker |
Negative |
| CD45 |
Pan-leukocyte marker |
Negative |
| CD133 |
Hematopoietic/angioblast marker |
Negative |
| STRO-1 |
MSC marker |
Negative |
| SSEA-4 |
Embryonic stem cell marker |
Negative |
| Nanog |
Embryonic stem cell marker |
Negative |
| CD9 |
MSC marker, associated with angiogenesis1 |
Positive |
| CD29 |
Adhesion molecule on mesenchymal and hepatic stem cells2 |
Positive |
| CD59 |
Complement inhibitor protein found on MSC3 and bone marrow side population CD34-stem cells4 |
Positive |
| CD73 |
Ecto-5'-nucleotidase, involved in migration of MSC |
Positive |
| CD41a |
Receptor for fibrinogen and vWF, found on MSC and platelets |
Positive |
| CD44 |
Hyaluronic acid receptor found on tissue stem cells and MSC |
Positive |
| CD90 |
Marker of T cells, hematopoietic and MSC |
Positive |
| CD105 |
Marker of tissue and MSC |
Positive |
| hTERT |
Telomerase reverse transcriptase |
Positive |
| Oct-4 |
Embryonic stem cell marker |
Positive |
|
1 Kim YJ, Yu JM, Joo HJ, Kim HK, Cho HH, Bae YC, Jung JS. Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells. Pflugers Arch. 2007 Aug 1. 2 Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H. Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation. Gastroenterology. 2007 Jun 20; 3 Izadpanah R, Joswig T, Tsien F, Dufour J, Kirijan JC, Bunnell BA. Characterization of multipotent mesenchymal stem cells from the bone marrow of rhesus macaques. Stem Cells Dev. 2005 Aug;14(4):440–51. 4 Preffer FI, Dombkowski D, Sykes M, Scadden D, Yang YG. Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization. Stem Cells. 2002;20(5):417–27. | ||
Meng et al. Journal of Translational Medicine 2007 5:57 doi:10.1186/1479-5876-5-57 |
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