Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream
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* Corresponding author: Woubalem Birmachu wbirmachu@comcast.net
Journal of Translational Medicine 2007, 5:7 doi:10.1186/1479-5876-5-7
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Research article
Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists Woubalem Birmachu, Raymond M Gleason, Barbara J Bulbulian, Christie L Riter, John P Vasilakos, Kenneth E Lipson, Yuri Nikolsky BMC Immunology 2007, 8:26 (12 October 2007) Instrumental in TLR7-mediated amplification of the innate response, plasmacytoid dendritic cells increase expression of a variety of type I interferons (IFNs) and IFN-inducible genes and activate specific anti-viral signaling pathways when stimulated with TLR7 agonists.
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Research
Monica C Panelli, Mitchell E Stashower, Herbert B Slade, Kina Smith, Christopher Norwood, Andrea Abati, Patricia Fetsch, Armando Filie, Shelley-Ann Walters, Calvin Astry, Eleonora Aricó, Yingdong Zhao, Silvia Selleri, Ena Wang, Francesco M Marincola Genome Biology 2007, 8:R8 (15 January 2007) An analysis of basal cell carcinoma subjected to local application of imiquimod revealed that most transcripts stimulated by imiquimod involve the activation of cellular innate and adaptive immune-effector mechanisms. |