Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream

doi:10.1186/1479-5876-5-7

Journal of Translational Medicine

Volume 5

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Torres A
Storey L
Anders M
Miller RL
Bulbulian BJ
Jin J
Raghavan S
Lee J
Slade HB
Birmachu W

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Storey L
Anders M
Miller RL
Bulbulian BJ
Jin J
Raghavan S
Lee J
Slade HB
Birmachu W
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Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream

Abel Torres¹ , Leslie Storey¹ , Makala Anders¹ , Richard L Miller² , Barbara J Bulbulian² , Jizhong Jin² , Shalini Raghavan² , James Lee³ , Herbert B Slade³ and Woubalem Birmachu²

¹Dermatology Office, Loma Linda University Medical Center, Loma Linda, California, USA

²Pharmacology, 3M Pharmaceuticals, St Paul, Minnesota, USA

³Medical & Scientific Affairs, 3M Pharmaceuticals, St Paul, Minnesota, USA

author email corresponding author email

Journal of Translational Medicine 2007, 5:7doi:10.1186/1479-5876-5-7


Published:	26 January 2007

Additional files

Additional file 1:

Imiquimod regulated genes. This file summarizes fold change in expression for 530 imiquimod regulated genes before and after treatment with imiquimod. Genes were selected on the basis of an ANOVA analysis comparing pre-treatment AK expression values to expression values during imiquimod treatment or 4-weeks after treatment with imiquimod, with P-values < 0.05

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Additional file 2:

Comparison of differential expression as measured by Affymetrix gene array and real time RT-PCR. This file summarizes a comparison of differential gene expression as measured by Affymetrix gene chip analysis and real time RT-PCR using low density TaqMan arrays. Expression changes for several toll-like receptors and other selected genes before and after treatment with imiquimod are reported.

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Additional file 3:

Imiquimod-induced genes with immune response gene ontology category and/or known to be IFNα/β-inducible. This file reports on expression changes before and after treatment with imiquimod, for selected genes with gene ontology category of immune response and (or) are know to be inducible by type 1 interferons.

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