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Gene Ontology Classification of Imiquimod-Induced Genes in AK Lesions |
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| Ontology |
Genes in the Data1 |
Annotated Genes2 |
P-value3 |
Increased Expression |
Decreased Expression |
Description of Processes and Specific Genes |
|
|
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| Total |
436 |
17479 |
369 |
67 |
||
| Response to stimuli |
137 |
2475 |
2.13E-19 |
125 |
12 |
defense response, response to external biotic stimuli including, pest and pathogens, antimicrobial, anti-fungal, anti-viral response |
| Defense response |
105 |
1174 |
1.54E-40 |
102 |
3 |
immune response, inflammatory response |
| Immune response |
106 |
1020 |
3.05E-40 |
104 |
2 |
cellular defense response, humoral defense response, antigen binding, pattern binding, cytokine synthesis, chemokine synthesis, antigen presentation processing, inflammatory response |
| Response to stress |
68 |
1337 |
1.77E-12 |
63 |
5 |
response to pest and pathogen, inflammatory response, response to virus, response to wounding |
| Inflammatory response |
25 |
244 |
4.35E-11 |
25 |
0 |
defensive reaction (by vertebrate tissue) to infection or injury |
| Response to wounding |
39 |
395 |
3.72E-16 |
39 |
0 |
defensive reaction (by vertebrate tissue) to physical injury |
| Signal transduction |
123 |
3547 |
4.70E-06 |
95 |
17 |
cytokine signaling, death receptor signaling, G-protein coupled receptor signaling, intigrin binding, MHC protein binding |
| Receptor activity |
72 |
1914 |
1.80E-07 |
62 |
10 |
chemokine receptors, pattern recognition receptors, immunoglobulin receptors, complement receptors, MHC I\MHCII receptors, scavenger receptors, Hematopoietin/interferon class (D200) receptors |
| Antigen binding |
8 |
91 |
2.66E-03 |
8 |
0 |
SCF1, IGLV2-14, LAG3, LILRA1, SLAMF1, TRA@, TRGC2, TAP2 |
| Carbohydrate binding |
16 |
326 |
1.18E-03 |
14 |
2 |
CCL8, CD69, CLEC4A, FCN1, FGFR2, GALNT7, HMMR, KLRC1/KLRC2, KLRF1, LGALS2, LGALS9, POSTN, PTN, SELL, SELPLG, SN |
| Pattern binding |
10 |
159 |
4.58E-02 |
8 |
2 |
CCL8, CD14, FGFR2, HMMR, POSTN, PTN, TLR2, TLR7, TLR8, TLR4 |
| Cytokine receptors |
9 |
99 |
1.97E-04 |
9 |
0 |
CCR5, CCR1, CD74, CSF2RB, CXCR4, IL10RA, IL1RL1, IL21R, TNFRSF1B |
| Cytokines |
12 |
257 |
1.11E-04 |
11 |
1 |
CCL3, CCL5, CCL8, CXCL5, CXCL10, CXCL11, CXCL12, CXCL16, TNFSF10, ECGF1, PTN, SLURP1 |
| Immunoglobulin binding |
4 |
25 |
1.56E-03 |
4 |
0 |
FCER1A, FCER1G, FCGR3B, 214511_x_at |
| Cystein type endopeptidase |
9 |
169 |
8.21E-03 |
9 |
0 |
CASP1, CASP8, CTSB, CTSL, CTSC, STSS, LGMN, TNFAIP3, USP18 |
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1Number of genes in the data for which annotation was found in the Gene Ontology database. 2Total number of gene with annotation in the Gene Ontology database. 3P-value for representation of gene ontology category in the data. | ||||||
Torres et al. Journal of Translational Medicine 2007 5:7 doi:10.1186/1479-5876-5-7 |
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