|
Multivariate Cox proportional hazards regression model for the primary outcome in women without obstructive CAD* |
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| Factor |
HR (95%CI) |
P |
|
|
||
| Clinical Model with Genetic Biomarkers (n = 396) |
||
| ADRB1 Gly389 carrier |
1.71 (0.91–3.19) |
0.09 |
| ADRB3 Arg64 carrier |
2.14 (1.06–4.30) |
0.03 |
| Black race |
1.77 (0.90–3.48) |
0.10 |
| Age (per decade) |
1.02 (0.99–1.05) |
0.25 |
| History of diabetes |
4.08 (2.01–8.28) |
< 0.001 |
| Ever-smoking |
8.13 (3.55–18.63) |
< 0.001 |
| Baseline systolic BP (per 10 mmHg) |
1.16 (0.99–1.36) |
0.06 |
| Body mass index (per 5 kg/m2) |
0.70 (0.54–0.92) |
0.01 |
| Clinical Model with Inflammatory and Genetic Biomarkers (n = 355) |
||
| ADRB1 Gly389 carrier |
1.67 (0.85–3.27) |
0.13 |
| ADRB3 Arg64 carrier |
2.43 (1.11–5.35) |
0.03 |
| Black race |
1.84 (0.92–3.67) |
0.08 |
| Age (per decade) |
1.01 (0.97–1.04) |
0.66 |
| History of diabetes |
3.78 (1.78–8.02) |
< 0.001 |
| Ever-smoking |
7.43 (3.13–17.63) |
< 0.001 |
| Baseline systolic BP (per 10 mmHg) |
1.17 (0.98–1.37) |
0.08 |
| Body mass index (per 5 kg/m2) |
0.70 (0.53–0.93) |
0.01 |
| 1 inflammatory biomarker in upper quartile* |
1.67 (0.75–3.77) |
0.21 |
| 2 or 3 inflammatory biomarkers in upper quartile |
4.30 (2.02–9.16) |
< 0.001 |
|
Abbreviations: HR, hazard ratio; 95%CI, 95% confidence interval* * Hypertension and dyslipidemia eliminated from models after stepwise selection | ||
Pacanowski et al. Journal of Translational Medicine 2008 6:11 doi:10.1186/1479-5876-6-11 |
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