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MILANO analysis for oncogenes and tumor suppressor genes |
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| Gene symbol |
Role1 |
Fold difference2 (NPC/NP) |
Description |
Map Location |
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| MIF |
Candidate oncogene |
10.72 |
macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
22q11.23 |
| BIRC5 |
Oncogene |
6.62 |
baculoviral IAP repeat-containing 5 (survivin) |
17q25 |
| PTTG1 |
Proto-oncogene |
7.35 |
pituitary tumor-transforming 1 |
5q35.1 |
| CCND2 |
Proto-oncogene |
20.15 |
cyclin D2 |
12p13 |
| ATM |
Tumor suppressor |
0.27 |
ataxia telangiectasia mutated (includes complementation groups A, C and D) |
11q22-q23 |
| FOXO1A |
Tumor suppressor |
0.20 |
forkhead box O1A (rhabdomyosarcoma) |
13q14.1 |
| TGFBR2 |
Tumor suppressor |
0.19 |
transforming growth factor, beta receptor II |
3p22 |
| PRKAR1A |
Tumor suppressor |
0.17 |
protein kinase, cAMP-dependent, regulatory, type I, alpha |
17q23-q24 |
| KLF5 |
Tumor suppressor |
0.17 |
Kruppel-like factor 5 (intestinal) |
13q22.1 |
| PDCD4 |
Tumor suppressor |
0.10 |
programmed cell death 4 (neoplastic transformation inhibitor) |
10q24 |
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1 Role: functions identified by MILANO 2 Fold difference: extracted from our microarray data. | ||||
Fang et al. Journal of Translational Medicine 2008 6:32 doi:10.1186/1479-5876-6-32 |
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