HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor

doi:10.1186/1479-5876-7-44

Journal of Translational Medicine

Volume 7

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Tsukahara T
Kawaguchi S
Torigoe T
Takahashi A
Murase M
Kano M
Wada T
Kaya M
Nagoya S
Yamashita T
Sato N

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Tsukahara T
Kawaguchi S
Torigoe T
Takahashi A
Murase M
Kano M
Wada T
Kaya M
Nagoya S
Yamashita T
Sato N
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HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor

Tomohide Tsukahara¹^,2 , Satoshi Kawaguchi¹ , Toshihiko Torigoe² , Akari Takahashi² , Masaki Murase¹^,2 , Masanobu Kano¹^,2 , Takuro Wada¹ , Mitsunori Kaya¹ , Satoshi Nagoya¹ , Toshihiko Yamashita¹ and Noriyuki Sato²

¹Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo, 060-8543, Japan

²Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan

author email corresponding author email

Journal of Translational Medicine 2009, 7:44doi:10.1186/1479-5876-7-44


Published:	12 June 2009

Additional files

Additional file 1:

Sequences and binding affinities of PBF-derived peptides with HLA-A*0201 binding motif. *Binding score was determined by BIMAS HLA Peptide Binding Predictions. ^†The affinity of each peptide (50 μg/ml) was evaluated by a HLA class I stabilization assay.

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Additional file 2:

Clinical picture and frequency of anti-PBF A2.2 peptide CTLs in PBMC of patients with osteosarcoma. P: primary tumor, M: metastatic tumor. ^†Frequency of anti-PBF A2.2 CTLs among CD8+ cells. ^‡Parentheses indicate that the tumor had been resected at the time of blood sampling. ^§Magnetically separated CD8+ cells. Irradiated peptide-pulsed CD8- cells were used as stimulator.

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