Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures

doi:10.1186/1479-5876-7-46

Journal of Translational Medicine

Volume 7

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Jazedje T
Perin PM
Czeresnia CE
Maluf M
Halpern S
Secco M
Bueno DF
Vieira NM
Zucconi E
Zatz M

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Jazedje T
Perin PM
Czeresnia CE
Maluf M
Halpern S
Secco M
Bueno DF
Vieira NM
Zucconi E
Zatz M
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Research

Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures

Tatiana Jazedje¹ , Paulo M Perin² , Carlos E Czeresnia³ , Mariangela Maluf² , Silvio Halpern² , Mariane Secco¹ , Daniela F Bueno¹ , Natassia M Vieira¹ , Eder Zucconi¹ and Mayana Zatz¹

¹Human Genome Research Center, Biosciences Institute, University of São Paulo, Brazil Rua do Matão, n° 106, Cidade Universitária São Paulo SP, CEP: 05508-090, Brazil

²CEERH Specialized Center for Human Reproduction, São Paulo, Brazil Rua Mato Grosso, n° 306 19° andar, Higienópolis São Paulo SP, CEP: 01239-040, Brazil

³Celula Mater, São Paulo, Brazil Al. Gabriel Monteiro da Silva, n° 802 São Paulo SP, CEP: 01442-000, Brazil

author email corresponding author email

Journal of Translational Medicine 2009, 7:46doi:10.1186/1479-5876-7-46


Published:	18 June 2009

Abstract

Background

The possibility of using stem cells for regenerative medicine has opened a new field of investigation. The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. The aim of this study was to isolate, expand, characterize and assess the differentiation potential of MSCs from human fallopian tubes (hFTs).

Methods

Lineages of hFTs were expanded, had their karyotype analyzed, were characterized by flow cytometry and underwent in vitro adipogenic, chondrogenic, osteogenic, and myogenic differentiation.

Results

Here we show for the first time that hFTs, which are discarded after some gynecological procedures, are a rich additional source of MSCs, which we designated as human tube MSCs (htMSCs).

Conclusion

Human tube MSCs can be easily isolated, expanded in vitro, present a mesenchymal profile and are able to differentiate into muscle, fat, cartilage and bone in vitro.