Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies

doi:10.1186/1479-5876-8-4

Journal of Translational Medicine

Volume 8

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Ren J
Saunders S
Wang E
Marincola FM
Stroncek DF

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This article is part of the series Tumor Immunology and Biological Cancer Therapy, edited by iSBTc (Pedro Romero).

Research

Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies

Ping Jin¹^* , Tae Hee Han¹^,2^* , Jiaqiang Ren¹ , Stefanie Saunders¹ , Ena Wang¹ , Francesco M Marincola¹ and David F Stroncek¹

¹Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA

²Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea

author email corresponding author email* Contributed equally

Journal of Translational Medicine 2010, 8:4doi:10.1186/1479-5876-8-4


Published:	15 January 2010

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Additional file 1:

Table S1: The 30 canonical pathways with the most differentially expressed DC genes for each of the 5 gene clusters. Canonical pathway analysis showed that genes in each of these 5 clusters belong to different pathways.

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Table S2. Immature DC Genes whose expression was up-regulated following LPS and IFN-γ stimulation. The specific genes that were differentially expressed among the DCs stimulated with LPS and IFN- γ for different durations of time and their fold-change, up-regulated genes summary. (t-test, p ≤ 0.001 compared to hr 0).

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Additional file 3:

Table S3. Immature DC Genes whose expression was down-regulated following LPS and IFN- γ stimulation. The specific genes that were differentially expressed among the DCs stimulated with LPS and IFN- γ for different durations of time and their fold-change, down-regulated genes summary. (t-test, p ≤ 0.001 compared to hr 0).

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Table S4. Soluble factor levels in DC cell culture supernatant whose expression was up-regulated following LPS and IFN- γ stimulation. Soluble factor levels in DC cell culture supernatant whose expression was up-regulated following LPS and IFN- γ stimulation.

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Table S5. Soluble factor levels and fold changes in mature DC culture supernatant after 24 hours of CD40 Ligand stimulation. Soluble factor levels and fold changes in mature DC culture supernatant after 24 hours of CD40 Ligand stimulation.

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