Distribution of Neural peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in brain infarct area. A) to E) Immunofluorescent staining (400 x) of PGC-1α (yellow arrows) and neuron (white arrows) in brain infarct area (n = 6). Both numbers of PGC-1α+ cells and neurons remarkably lower in group 2 than in other groups, significantly lower in group 3 and 4 than in group 1 and 5, and significantly reduced in group 5 compared with group 1. F) and G) † vs. other groups, p < 0.0001 (ANOVA test). Symbols (*, †, ‡, §) in (F) and (G) indicate significance (at 0.05 level) (by Scheffe multiple-comparison post hoc test). Scale bars in right lower corner represent 20 μm.
Yuen et al. Journal of Translational Medicine 2011 9:141 doi:10.1186/1479-5876-9-141