Most Recent Articles: Journal of Translational Medicinehttps://translational-medicine.biomedcentral.comMost Recent Articles: Journal of Translational MedicineSingle-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancerhttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05057-2Non-small cell lung cancer (NSCLC) often exhibits resistance to radiotherapy, posing significant treatment challenges. This study investigates the role of SMAD3 in NSCLC, focusing on its potential in influenci...ResearchSat, 16 Mar 2024 00:00:00 GMThttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05057-2Fushi Han, Shuzhen Chen, Kangwei Zhang, Kunming Zhang, Meng Wang and Peijun Wang2024-03-16T00:00:00ZRedox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesishttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05068-zProtein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic cancer development remains poorly understood.ResearchSat, 16 Mar 2024 00:00:00 GMThttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05068-zChaochao Tan, Lichun Chen, Xiaoyu Guan, Wenyi Huang, Yinhong Feng, Ziyi Li, Ling Wu, Xiangping Huang, Qianhui Ouyang, Sixiang Liu, Ying Huang and Jiliang Hu2024-03-16T00:00:00ZLow-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP–RIPK1–NF-κB axis and influencing autophagyhttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05086-xOsteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even...ResearchSat, 16 Mar 2024 00:00:00 GMThttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05086-xChunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo and Tao Xu2024-03-16T00:00:00ZLactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine modelhttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05064-3Lactate is traditionally recognized as a by-product of anaerobic metabolism. However, lactate is a preferred oxidative substrate for stressed myocardium. Exogenous lactate infusion increases cardiac output (CO...ResearchSat, 16 Mar 2024 00:00:00 GMThttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05064-3Oskar Kjærgaard Hørsdal, Niels Moeslund, Kristoffer Berg-Hansen, Roni Nielsen, Niels Møller, Hans Eiskjær, Henrik Wiggers and Nigopan Gopalasingam2024-03-16T00:00:00ZPredictive biomarkers for anti-TNF alpha therapy in IBD patientshttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05058-1Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition characterized by severe gut inflammation, commonly presenting as Crohn’s disease, ulcerative colitis or categorized as IBD- unclassified...ReviewSat, 16 Mar 2024 00:00:00 GMThttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05058-1Manoj Kumar, Selvasankar Murugesan, Nazira Ibrahim, Mamoun Elawad and Souhaila Al Khodor2024-03-16T00:00:00Z