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1: Lancet. 2000 Sep 16;356(9234):999-1000.
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Transmission of BSE by blood transfusion in sheep.

Houston F, Foster JD, Chong A, Hunter N, Bostock CJ.

We have shown that it is possible to transmit bovine spongiform encephalopathy (BSE) to a sheep by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. BSE and variant Creutzfeldt-Jakob disease (vCJD) In human beings are caused by the same infectious agent, and the sheep-BSE experimental model has a similar pathogenesis to that of human vCJD. Although UK blood transfusions are leucodepleted--a possible protective measure against any risk from blood transmission--this report suggests that blood donated by symptom-free vCJD-infected human beings may represent a risk of spread of vCJD infection among the human population of the UK.

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PMID: 11041403 [PubMed - indexed for MEDLINE]