Acetazolamide-induced nephrolithiasis: implications for treatment of neuromuscular disorders.
Tawil R, Moxley RT 3rd, Griggs RC.
Neuromuscular Disease Center, University of Rochester School of Medicine and Dentistry, NY 14642.
Carbonic anhydrase inhibitors can cause nephrolithiasis. We studied 20 patients receiving long-term carbonic anhydrase inhibitor treatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed renal calculi. Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in another, permitting continued treatment. Renal function remained normal in all patients. Nephrolithiasis is a complication of acetazolamide but does not preclude its use.
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PMID: 8170551 [PubMed - indexed for MEDLINE]