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1: Int J Cancer. 1998 Jan 19;75(2):266-76.
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Priming in the brain, an immunologically privileged organ, elicits anti-tumor immunity.

Fathallah-Shaykh HM, Gao W, Cho M, Herrera MA.

Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235-9036, USA. fathalla@utsw.swmed.edu

A crucial question in the study of tumor neuro-immunology concerns the capacity of the central nervous system to initiate and execute an immune response. In a 100% fatal rat malignant glioma model, genetically modified tumors secreting INF-gamma intracerebrally generate an immune response resulting in a substantial increase in survival time, tumor rejection and specific systemic immunity. Tumors modified to secrete IL-2 alone do not change the biologic behavior of transfected gliomas. INF-gamma induces elevated expression of major-histocompatibility-complex-class-I and -class-II molecules in microglia throughout the brain and invokes enhanced tumor infiltration by CD4, CD8 and NK cells. These findings demonstrate successful immunization against a central-nervous-system tumor by direct priming in the brain with a live growth-competent tumor vaccine.

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PMID: 9462718 [PubMed - indexed for MEDLINE]