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Disease Biomarkers Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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1.

Review   Open Access

Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies

Federico Serana, Marco Chiarini, Cinzia Zanotti, Alessandra Sottini, Diego Bertoli, Andrea Bosio, Luigi Caimi, Luisa Imberti Journal of Translational Medicine 2013, 11:119 (9 May 2013)

Abstract | Provisional PDF | PubMed

2.

Research   Open Access

Nuclear beta-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer

Xi-Qing Li, Xing-Long Yang, Gong Zhang, Si-Pei Wu, Xu-Bing Deng, Sheng-Jun Xiao, Qiu-Zhen Liu, Kai-Tai Yao, Guang-Hui Xiao Journal of Translational Medicine 2013, 11:114 (6 May 2013)

Abstract | Provisional PDF | PubMed

3.

Research   Open Access

Expression of gamma-aminobutyric acid receptors on neoplastic growth and prediction of prognosis in non-small cell lung cancer

Xiaoxue Zhang, Rong Zhang, Yuanjie Zheng, Jianfei Shen, Dakai Xiao, Jin Li, Xiaoshun Shi, Liyan Huang, Hailing Tang, Jun Liu, Jianxing He, Haibo Zhang Journal of Translational Medicine 2013, 11:102 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

4.

Research   Open Access

BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas

Zhaoshi Bao, Chuanbao Zhang, Wei Yan, Yanwei Liu, Mingyang Li, Wei Zhang, Tao Jiang Journal of Translational Medicine 2013, 11:100 (16 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

Research   Open Access Highly Accessed

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology

Elizabeth Ann Stringer, Katharine Susanne Baker, Ian R Carroll, Jose G Montoya, Lily Chu, Holden T Maecker, Jarred W Younger Journal of Translational Medicine 2013, 11:93 (9 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

6.

Research   Open Access

Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma

Elena Dementyeva, Fedor Kryukov, Lenka Kubiczkova, Pavel Nemec, Sabina Sevcikova, Ivana Ihnatova, Jiri Jarkovsky, Jiri Minarik, Zdena Stefanikova, Petr Kuglik, Roman Hajek Journal of Translational Medicine 2013, 11:77 (23 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

Methodology   Open Access

Development of a robust flow cytometry-based pharmacodynamic assay to detect phospho-protein signals for phosphatidylinositol 3-kinase inhibitors in multiple myeloma

Congfen Li, Chikara Takahashi, Liangxuan Zhang, Mahrukh Huseni, Basha Stankovich, Haider Mashhedi, Joanna Lee, Dorothy French, Jeff Eastham Anderson, Doris Kim, Kathy Howell, Matthew J Brauer, Marcin Kowanetz, Yibing Yan, Eric Humke, Allen Ebens, Garret Hampton, Mark R Lackner, Priti Hegde, Shidong Jia Journal of Translational Medicine 2013, 11:76 (23 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

Research   Open Access

Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events

Vafa Shahabi, David Berman, Scott D Chasalow, Lisu Wang, Zenta Tsuchihashi, Beihong Hu, Lisa Panting, Maria Jure-Kunkel, Rui-Ru Ji Journal of Translational Medicine 2013, 11:75 (22 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

Research   Open Access

A three-gene signature as potential predictive biomarker for irinotecan sensitivity in gastric cancer

Jie Shen, Jia Wei, Hao Wang, Guofeng Yue, Lixia Yu, Yang Yang, Li Xie, Zhengyun Zou, Xiaoping Qian, Yitao Ding, Wenxian Guan, Baorui Liu Journal of Translational Medicine 2013, 11:73 (22 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

Research   Open Access

Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy

Shien Zou, Xin Li, Yi Feng, Shan Sun, Jin Li, Emil Egecioglu, HÃ¥kan Billig, Ruijin Shao Journal of Translational Medicine 2013, 11:44 (19 February 2013)

Abstract | Full text | PDF | PubMed

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