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Clinical translation Section edited by George Coukos

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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1.

Research   Open Access

Hematopoietic stem cell transplantation induces immunologic tolerance in renal transplant patients via modulation of inflammatory and repair processes

Duojiao Wu, Guisheng Qi, Xuanchuan Wang, Ming Xu, Ruiming Rong, Xiangdong Wang, Tongyu Zhu Journal of Translational Medicine 2012, 10:182 (31 August 2012)

Abstract | Full text | PDF | PubMed

2.

Research   Open Access Highly Accessed

A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer

Lana E Kandalaft, Daniel J Powell, George Coukos Journal of Translational Medicine 2012, 10:157 (3 August 2012)

Abstract | Full text | PDF | PubMed

3.

Research   Open Access

A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial

Nehal N Mehta, Sean P Heffron, Parth N Patel, Jane Ferguson, Rachana D Shah, Christine C Hinkle, Parasuram Krishnamoorthy, Rhia Shah, Jennifer Tabita-Martinez, Karen Terembula, Stephen R Master, Michael R Rickels, Muredach P Reilly Journal of Translational Medicine 2012, 10:124 (18 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

Research   Open Access

Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study

Charles Kunos, Tomas Radivoyevitch, Fadi W Abdul-Karim, James Fanning, Ovadia Abulafia, Albert J Bonebrake, Lydia Usha Journal of Translational Medicine 2012, 10:79 (27 April 2012)

Abstract | Full text | PDF | PubMed

5.

Research   Open Access

Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide

Julio D Duarte, Issam Zineh, Ben Burkley, Yan Gong, Taimour Y Langaee, Stephen T Turner, Arlene B Chapman, Eric Boerwinkle, John G Gums, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Kent R Bailey, Roger B Fillingim, Bruce C Kone, Julie A Johnson Journal of Translational Medicine 2012, 10:56 (22 March 2012)

Abstract | Full text | PDF | PubMed

6.

Research   Open Access

Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response

Stephen T Turner, Gary L Schwartz, Arlene B Chapman, Amber L Beitelshees, John G Gums, Rhonda M Cooper-DeHoff, Eric Boerwinkle, Julie A Johnson, Kent R Bailey Journal of Translational Medicine 2012, 10:47 (13 March 2012)

Abstract | Full text | PDF | PubMed

7.

Research   Open Access

Performance of a multianalyte test as an aid for the diagnosis of ovarian cancer in symptomatic women

Dominic J Autelitano, Linda Raineri, Kate Knight, Kelly Bannister, Gregory E Rice Journal of Translational Medicine 2012, 10:45 (12 March 2012)

Abstract | Full text | PDF | PubMed

8.

Research   Open Access

PDCD6 is an independent predictor of progression free survival in epithelial ovarian cancer

Dan Su, Haiyan Xu, Jianguo Feng, Yun Gao, Linhui Gu, Lisha Ying, Dionyssios Katsaros, Herbert Yu, Shenhua Xu, Ming Qi Journal of Translational Medicine 2012, 10:31 (27 February 2012)

Abstract | Full text | PDF | PubMed

9.

Research   Open Access

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

Pietro Bulian, Davide Rossi, Francesco Forconi, Giovanni Del Poeta, Francesco Bertoni, Emanuele Zucca, Marco Montillo, Gabriele Pozzato, Giovanni D'Arena, Dimitar G Efremov, Roberto Marasca, Francesco Lauria, Gianluca Gaidano, Valter Gattei, Luca Laurenti Journal of Translational Medicine 2012, 10:18 (30 January 2012)

Abstract | Full text | PDF | PubMed

10.

Research   Open Access

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

Chao Ren, Miao-zhen Qiu, De-shen Wang, Hui-yan Luo, Dong-sheng Zhang, Zhi-qiang Wang, Feng-hua Wang, Yu-hong Li, Zhi-wei Zhou, Rui-hua Xu Journal of Translational Medicine 2012, 10:16 (27 January 2012)

Abstract | Full text | PDF | PubMed

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