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Combination strategies Section edited by Paolo A. Ascierto

This section aims to provide a focal point for research that highlights combination therapies, where two or more medications or therapies are strategically combined to improve the treatment of cancer, chronic infections, transplantation and potentially other complex and multi-factorial diseases.

Increasingly detailed understanding of the molecular basis driving complex disease has led to the identifications of new agents that target specific pathways. In some cases treatment of appropriately selected patients has led to striking clinical response, however both primary and secondary resistance mechanisms limited the success of many of these agents. It has become clear that combining or sequencing treatment modalities may en to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

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1.

Research   Open Access

Comparative analysis of cancer vaccine settings for the selection of an effective protocol in mice

Francesca Kalli, Rodolfo Machiorlatti, Florinda Battaglia, Alessia Parodi, Giuseppina Conteduca, Francesca Ferrera, Michele Proietti, Samuele Tardito, Marina Sanguineti, Enrico Millo, Daniela Fenoglio, Raffaele De Palma, Giorgio Inghirami, Gilberto Filaci Journal of Translational Medicine 2013, 11:120 (12 May 2013)

Abstract | Provisional PDF | PubMed

2.

Research   Open Access

Stromal cell derived factor-1alpha protects stem cell derived insulin-producing cells from Glucotoxicity under high glucose conditions in-vitro and ameliorates drug induced diabetes in rats

Muhammad Tariq, Muhammad Sharif Masoud, Azra Mehmood, Shaheen N Khan, Sheikh Riazuddin Journal of Translational Medicine 2013, 11:115 (6 May 2013)

Abstract | Provisional PDF | PubMed

3.

Research   Open Access

Phase 1 studies of the safety and immunogenicity of electroporated HER2/CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors

Claudia Marcela Diaz, Alberto Chiappori, Luigi Aurisicchio, Ansuman Bagchi, Jason Clark, Sheri Dubey, Arthur Fridman, Jesus C Fabregas, John Marshall, Elisa Scarselli, Nicola La Monica, Gennaro Ciliberto, Alberto J Montero Journal of Translational Medicine 2013, 11:62 (8 March 2013)

Abstract | Full text | PDF | PubMed

4.

Commentary   Open Access

Do BRAF inhibitors select for populations with different disease progression kinetics?

Paolo Antonio Ascierto, Ester Simeone, Antonio Maria Grimaldi, Marcello Curvietto, Assunta Esposito, Giuseppe Palmieri, Nicola Mozzillo Journal of Translational Medicine 2013, 11:61 (8 March 2013)

Abstract | Full text | PDF | PubMed

5.

Protocol   Open Access

Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma

Antonio Daponte, Simona Signoriello, Luigi Maiorino, Bruno Massidda, Ester Simeone, Antonio Maria Grimaldi, Corrado Caracò, Giuseppe Palmieri, Antonio Cossu, Gerardo Botti, Antonella Petrillo, Secondo Lastoria, Ernesta Cavalcanti, Pasquale Aprea, Nicola Mozzillo, Ciro Gallo, Giuseppe Comella, Paolo Antonio Ascierto, on behalf of the Southern Italy Cooperative Oncology Group (SICOG) Journal of Translational Medicine 2013, 11:38 (13 February 2013)

Abstract | Full text | PDF | PubMed

6.

Research   Open Access

High efficacy of CpG-ODN, Cetuximab and Cisplatin combination for very advanced ovarian xenograft tumors

Michele Sommariva, Michelandrea de Cesare, Alessandra Meini, Alessandra Cataldo, Nadia Zaffaroni, Elda Tagliabue, Andrea Balsari Journal of Translational Medicine 2013, 11:25 (29 January 2013)

Abstract | Full text | PDF | PubMed

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Research   Open Access

Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo

Chung-Wei Fan, Chun-Yu Chen, Kuei-Tien Chen, Chia-Rui Shen, Yung-Bin Kuo, Ya-Shan Chen, Yeh-Pin Chou, Wei-Shan Wei, Err-Cheng Chan Journal of Translational Medicine 2012, 10:254 (24 December 2012)

Abstract | Full text | PDF | PubMed

8.

Research   Open Access

NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

Simona Caporali, Lauretta Levati, Grazia Graziani, Alessia Muzi, Maria Grazia Atzori, Enzo Bonmassar, Giuseppe Palmieri, Paolo A Ascierto, Stefania D’Atri Journal of Translational Medicine 2012, 10:252 (21 December 2012)

Abstract | Full text | PDF | PubMed

9.

Research   Open Access Highly Accessed

MGMT promoter methylation status and MGMT and CD133 immunohistochemical expression as prognostic markers in glioblastoma patients treated with temozolomide plus radiotherapy

Consolación Melguizo, Jose Prados, Beatriz González, Raul Ortiz, Angel Concha, Pablo Alvarez, Roberto Madeddu, Gloria Perazzoli, Jaime Oliver, Rodrigo López, Fernando Rodríguez-Serrano, Antonia Aránega Journal of Translational Medicine 2012, 10:250 (17 December 2012)

Abstract | Full text | PDF | PubMed

10.

Research   Open Access

Topoisomerase II alpha gene amplification is a favorable prognostic factor in patients with HER2-positive metastatic breast cancer treated with trastuzumab

George Fountzilas, Christos Christodoulou, Mattheos Bobos, Vassiliki Kotoula, Anastasia G Eleftheraki, Ioannis Xanthakis, Anna Batistatou, George Pentheroudakis, Nikolaos Xiros, Irene Papaspirou, Anna Koumarianou, Pavlos Papakostas, Dimitrios Bafaloukos, Dimosthenis V Skarlos, Konstantine T Kalogeras Journal of Translational Medicine 2012, 10:212 (23 October 2012)

Abstract | Full text | PDF | PubMed

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