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Cell, tissue and gene therapy Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

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1.

Research   Open Access

A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia

Pawan K Gupta, Anoop Chullikana, Rajiv Parakh, Sanjay Desai, Anjan Das, Sanjay Gottipamula, Sagar Krishnamurthy, Naveen Anthony, Arun Pherwani, Anish S Majumdar Journal of Translational Medicine 2013, 11:143 (10 June 2013)

Abstract | Provisional PDF | PubMed

2.

Research   Open Access

Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation

Yanna Si, Hongguang Bao, Liu Han, Hongwei Shi, Yuan Zhang, Li Xu, Chenhui Liu, Jinsong Wang, Xiaobing Yang, Akbar Vohra, Daqing Ma Journal of Translational Medicine 2013, 11:141 (9 June 2013)

Abstract | Provisional PDF | PubMed

3.

Review   Open Access

Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction?

Thomas E Ichim, Timothy Warbington, Octav Cristea, Joseph L Chin, Amit N Patel Journal of Translational Medicine 2013, 11:139 (9 June 2013)

Abstract | Provisional PDF | PubMed

4.

Research   Open Access

Transplantation of modified human adipose derived stromal cells expressing VEGF165 results in more efficient angiogenic response in ischemic skeletal muscle

Evgeny K Shevchenko, Pavel I Makarevich, Zoya I Tsokolaeva, Maria A Boldyreva, Veronika Sysoeva, Vsevolod A Tkachuk, Yelena V Parfyonova Journal of Translational Medicine 2013, 11:138 (6 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

Research   Open Access

Autologous fat transfer with in-situ mediation (AIM): a novel and compliant method of adult mesenchymal stem cell therapy

Allan Y Wu, David M Morrow Journal of Translational Medicine 2013, 11:136 (31 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

6.

Research   Open Access

Id1 enhances human ovarian cancer endothelial progenitor cell angiogenesis via PI3K/Akt and NF-kappaB/MMP-2 signaling pathways

Yajuan Su, Lingjuan Gao, Lichen Teng, Ying Wang, Jialin Cui, Shiyun Peng, Songbin Fu Journal of Translational Medicine 2013, 11:132 (29 May 2013)

Abstract | Provisional PDF | PubMed

7.

Research   Open Access

A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells

Minchao Cai, Jing Wu, Chaoming Mao, Jianmin Ren, Pu Li, Xiao Li, Jiuchang Zhong, Chundi Xu, Tong Zhou Journal of Translational Medicine 2013, 11:103 (29 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

Research   Open Access

Annexin A1 protein regulates the expression of PMVEC cytoskeletal proteins in CBDL rat serum-induced pulmonary microvascular remodeling

Bin Yi, Jing Zeng, Guansong Wang, Guisheng Qian, Kaizhi Lu Journal of Translational Medicine 2013, 11:98 (15 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

Research   Open Access

Intra-osseous injection of donor mesenchymal stem cell (MSC) into the bone marrow in living donor kidney transplantation; a pilot study

Hyunah Lee, Jae Berm Park, Sanghoon Lee, Soyoung Baek, HyunSoo Kim, Sung Joo Kim Journal of Translational Medicine 2013, 11:96 (11 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

Research   Open Access

Extracellular matrix proteins and displacement of cultured fibroblasts from duodenal biopsies in celiac patients and controls

Leda Roncoroni, Luca Elli, Maria Teresa Bardella, Gianluca Perrucci, Michele Ciulla, Vincenza Lombardo, Carolina Tomba, Dario Conte, Luisa Doneda Journal of Translational Medicine 2013, 11:91 (8 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

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