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Patient-targeted molecular therapies Section edited by Francesco Chiappelli

The mission of this section is to enrich the overall mandate of the journal through effectively capturing the growing sector of molecular targeted therapies with broad therapeutic applicability, benefiting from a patient-centered outcomes research focus and translational effectiveness approach, to generate adequate information during research and early development stages, as well as consensus on the best available evidence.

This section has a unique and defining objective and rationale relative to the other sections that focus primarily on translational immunology and oncology. In contrast, this section will add the complementary discourse between translational research and translational effectiveness. In doing so, it will expand the overall vision of the journal, and address current, timely and cutting edge research and reviews about patient-centered targeted therapies, in context of translating cost and benefit effectiveness to specific clinical settings.

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1.

Research   Open Access

Low expression of LOC285194 is associated with poor prognosis in colorectal cancer

Peng Qi, Mi-die Xu, Shu-juan Ni, Dan Huang, Ping Wei, Cong Tan, Xiao-yan Zhou, Xiang Du Journal of Translational Medicine 2013, 11:122 (16 May 2013)

Abstract | Provisional PDF | PubMed

2.

Research   Open Access

Basigin-2 is the predominant basigin isoform that promotes tumor cell migration and invasion and correlates with poor prognosis in epithelial ovarian cancer

Shu-Hua Zhao, Yu Wang, Li Wen, Zhen-Bo Zhai, Zhen-Hua Ai, Nian-Ling Yao, Li Wang, Wen-Chao Liu, Bi-Liang Chen, Yu Li, Hong Yang Journal of Translational Medicine 2013, 11:92 (8 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

3.

Research   Open Access

Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma

Prabha B Mishra, Aurelio S Lobo, Kalpana S Joshi, Maggie J Rathos, Gopinath A Kumar, Muralidhara Padigaru Journal of Translational Medicine 2013, 11:42 (18 February 2013)

Abstract | Provisional PDF | PubMed

4.

Research   Open Access

Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer

Marina França de Resende, Samantha Vieira, Ludmilla Thomé Domingos Chinen, Francesco Chiappelli, Francisco Paulo da Fonseca, Gustavo Cardoso Guimarães, Fernando Augusto Soares, Ivan Neves, Simone Pagotty, Peter A Pellionisz, Andre Barkhordarian, Xenia Brant, Rafael Malagoli Rocha Journal of Translational Medicine 2013, 11:36 (11 February 2013)

Abstract | Full text | PDF | PubMed

5.

Research   Open Access

Somatostatin-based radiotherapy with [90Y-DOTA]-TOC in neuroendocrine tumors: long-term outcome of a phase I dose escalation study

Nicolas Marincek, Ann-Catherine Jörg, Philippe Brunner, Christian Schindler, Michael T Koller, Christoph Rochlitz, Jan Müller-Brand, Helmut R Maecke, Matthias Briel, Martin A Walter Journal of Translational Medicine 2013, 11:17 (15 January 2013)

Abstract | Full text | PDF | PubMed

6.

Research   Open Access

Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

Shuwei Qiu, Sheng Lin, Dan Hu, Yimin Feng, Yang Tan, Ying Peng Journal of Translational Medicine 2013, 11:10 (9 January 2013)

Abstract | Full text | PDF | PubMed

7.

Methodology   Open Access

NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

Maryam Zadeh-Khorasani, Thomas Nolte, Thomas D Mueller, Markos Pechlivanis, Franziska Rueff, Andreas Wollenberg, Gert Fricker, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp Journal of Translational Medicine 2013, 11:4 (7 January 2013)

Abstract | Full text | PDF | PubMed

8.

Research   Open Access

Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)

Yi-Che Changchien, Péter Tátrai, Gergő Papp, Johanna Sápi, László Fónyad, Miklós Szendrői, Zsuzsanna Pápai, Zoltán Sápi Journal of Translational Medicine 2012, 10:216 (30 October 2012)

Abstract | Full text | PDF | PubMed

9.

Research   Open Access

Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma

Zhao-lei Zeng, Wen-jing Wu, Jing Yang, Zhen-jie Tang, Dong-liang Chen, Miao-zhen Qiu, Hui-yan Luo, Zhi-qiang Wang, Ying Jin, De-shen Wang, Rui-hua Xu Journal of Translational Medicine 2012, 10:181 (31 August 2012)

Abstract | Full text | PDF | PubMed

10.

Research   Open Access

Prognostic significance of c-KIT in vulvar cancer: bringing this molecular marker from bench to bedside

Beatriz de Melo Maia, André Lavorato-Rocha, Iara Rodrigues, Glauco Baiocchi, Flávia Cestari, Monica Stiepcich, Ludmila Chinen, Kátia C Carvalho, Fernando Soares, Rafael Rocha Journal of Translational Medicine 2012, 10:150 (28 July 2012)

Abstract | Full text | PDF | PubMed

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